PXD022028-2

PXD022028 is an original dataset announced via ProteomeXchange.

Title	Host cholesterol modulates the generation and enrichment of persister population during Mycobacterium tuberculosis infection.
Description	Post-translational modifications (PTMs) confer diversity to regulatory mechanisms that control various cellular pathways. Two of the most extensively studied PTMs are phosphorylation and acetylation. Together, they are known to regulate the stability and activity of proteins in both eukaryotes and prokaryotes. Lysine acetylation is known to regulate various cellular pathways conserved across species including mycobacteria. In order to confirm the cholesterol mediated deacetylation of anti-toxin in Mycobacteria, we did mass spectrometry of BCG strain overexpressing the toxin (vapC12)–antitoxin (vapB12)-His(6X) locus grown in glycerol and cholesterol media.
HostingRepository	PRIDE
AnnounceDate	2020-11-02
AnnouncementXML	Submission_2020-11-02_05:33:41.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Renu Goel
SpeciesList	scientific name: Mycobacterium tuberculosis M24; NCBI TaxID: 1268063;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-16 03:46:13	ID requested
1	2020-10-16 06:36:54	announced
⏵ 2	2020-11-02 05:33:41	announced	2020-11-02: Updated project metadata.

Dataset with its publication pending

submitter keyword: proteomics, LC-MS/MS

Dr Amit Pandey
contact affiliation	Translational Health Science and Technology Institute
contact email	amitpandey@thsti.res.in
lab head
Renu Goel
contact affiliation	Translational Health Science and technology Institute
contact email	drrenugoel@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/10/PXD022028

PRIDE project URI

• PRIDE
  1. PXD022028
     1. Label: PRIDE project
     2. Name: Host cholesterol modulates the generation and enrichment of persister population during Mycobacterium tuberculosis infection.