PXD020018-3

PXD020018 is an original dataset announced via ProteomeXchange.

Title	Identification of SAMD9 and SAMD9L interactome in HEK293T cells
Description	Recently, heterozygous germline mutations were identified in sterile alpha motif (SAM) domain-9 (SAMD9) and its paralog, SAMD9-like (SAMD9L) in children with monosomy 7 mediated MDS. Expression of SAMD9 and SAMD9L is induced by interferons and other inflammatory stimuli and causes reduced cell division and cell growth and most pathogenic mutations found in patients dramatically enhance these effects. The goal of this project is to identify the interactome of SAMD9 and SAMD9L to better understand their role in cell cycle and proliferation regulation
HostingRepository	PRIDE
AnnounceDate	2021-03-25
AnnouncementXML	Submission_2021-03-24_23:30:34.419.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vishwajeeth Pagala
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-25 16:09:03	ID requested
1	2021-03-24 10:08:42	announced
2	2021-03-24 23:28:25	announced	2021-03-25: Updated project metadata.
⏵ 3	2021-03-24 23:30:35	announced	2021-03-25: Updated project metadata.

Thomas ME, Abdelhamed S, Hiltenbrand R, Schwartz JR, Sakurada SM, Walsh M, Song G, Ma J, Pruett-Miller SM, Klco JM, Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells. Leukemia, 35(11):3232-3244(2021) [pubmed]

10.1038/S41375-021-01212-6;

submitter keyword: SAMD9

SAMD9L

pediatric MDS

proteomics

Jeffery Klco
contact affiliation	Associate Member, Hematological Malignancies Program St. Jude Children's Research Hospital Memphis-TN UA
contact email	jeffery.klco@stjude.org
lab head
Vishwajeeth Pagala
contact affiliation	St. Jude Children's Research Hospital
contact email	vishwajeeth.pagala@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD020018

PRIDE project URI

• PRIDE
  1. PXD020018
     1. Label: PRIDE project
     2. Name: Identification of SAMD9 and SAMD9L interactome in HEK293T cells