PXD020002-2

PXD020002 is an original dataset announced via ProteomeXchange.

Title	Paracrine interactions between epithelial cells promote colon cancer growth
Description	Tumors are complex ecosystems composed of different types of cells that communicate and influence each other. While the critical role of stromal cells in affecting tumor growth is well established, the impact of mutant cancer cells on healthy surrounding tissues remains poorly defined. Here, we uncovered a paracrine mechanism by which intestinal cancer cells reactivate fetal and regenerative Yap-associated transcriptional programs in neighboring wildtype epithelial cells, rendering them adapted to thrive in the tumor context. We identified the glycoprotein Thrombospondin-1 (Thbs1) as the essential factor that mediates non-cell autonomous morphological and transcriptional responses. Importantly, Thbs1 is associated with bad prognosis in several human cancers. This study reveals the Thbs1-YAP axis as the mechanistic link mediating paracrine interactions between epithelial cells, promoting tumor formation and progression.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:36:03.162.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Valentin SABATET
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-24 08:00:42	ID requested
1	2022-05-09 00:19:16	announced
⏵ 2	2024-10-22 05:36:03	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Intestine, Organoids, SILAC, conditioned medium, Tumoroids

Damarys Loew
contact affiliation	Head of the Curie Institute Mass Spectrometry Platform
contact email	damarys.loew@curie.fr
lab head
Valentin SABATET
contact affiliation	Curie Institute
contact email	valentin.sabatet@curie.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD020002

PRIDE project URI

• PRIDE
  1. PXD020002
     1. Label: PRIDE project
     2. Name: Paracrine interactions between epithelial cells promote colon cancer growth