PXD020002 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Paracrine interactions between epithelial cells promote colon cancer growth |
Description | Tumors are complex ecosystems composed of different types of cells that communicate and influence each other. While the critical role of stromal cells in affecting tumor growth is well established, the impact of mutant cancer cells on healthy surrounding tissues remains poorly defined. Here, we uncovered a paracrine mechanism by which intestinal cancer cells reactivate fetal and regenerative Yap-associated transcriptional programs in neighboring wildtype epithelial cells, rendering them adapted to thrive in the tumor context. We identified the glycoprotein Thrombospondin-1 (Thbs1) as the essential factor that mediates non-cell autonomous morphological and transcriptional responses. Importantly, Thbs1 is associated with bad prognosis in several human cancers. This study reveals the Thbs1-YAP axis as the mechanistic link mediating paracrine interactions between epithelial cells, promoting tumor formation and progression. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-09 |
AnnouncementXML | Submission_2022-05-09_00:19:16.147.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Valentin SABATET |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-06-24 08:00:42 | ID requested | |
⏵ 1 | 2022-05-09 00:19:16 | announced | |
2 | 2024-10-22 05:36:03 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Intestine, Organoids, Tumoroids, SILAC, conditioned medium |
Contact List
Damarys Loew |
contact affiliation | Head of the Curie Institute Mass Spectrometry Platform |
contact email | damarys.loew@curie.fr |
lab head | |
Valentin SABATET |
contact affiliation | Curie Institute |
contact email | valentin.sabatet@curie.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD020002 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD020002
- Label: PRIDE project
- Name: Paracrine interactions between epithelial cells promote colon cancer growth