PXD018743-2

PXD018743 is an original dataset announced via ProteomeXchange.

Title	Ubiquitination profile of polarized macrophages
Description	Previous studies linked mac activation with the ubiquitination (ub) status of key proteins in inflammatory signal pathways. Lysine-48 ub (K48-ub) of the NF-κB inhibitor (IκB), the final checkpoint of the NFκB pathway, leads to IκB degradation and consequent NF-κB-associated inflammation. In contrast, TRAF6, an upstream positive regulator of the NF-κB pathway, is modulated by K63-ub, leading to its conformational change and activation. However, a comprehensive analysis of ub profiles of polarized macs has not been reported. If a unique ub signature is associated with individual mac subsets is not known.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:10:17.059.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xi Lin
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-22 15:23:28	ID requested
1	2020-08-05 22:44:50	announced
⏵ 2	2024-10-22 05:10:19	announced	2024-10-22: Updated project metadata.

Lin X, Zhang H, Boyce BF, Xing L, is associated with increased pro-inflammatory polarization of murine macrophages deficient in the E3 ligase ITCH. J Biol Chem, 295(33):11764-11775(2020) [pubmed]

10.1074/jbc.ra120.014298;

submitter keyword: Ubiquitination, Inflammation, Macrophage polarization, LC-MS/MS

Lianping Xing
contact affiliation	University of Rochester
contact email	Lianping_Xing@urmc.rochester.edu
lab head
Xi Lin
contact affiliation	University of Rochester
contact email	Xi_Lin@urmc.rochester.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/08/PXD018743

PRIDE project URI

• PRIDE
  1. PXD018743
     1. Label: PRIDE project
     2. Name: Ubiquitination profile of polarized macrophages