⮝ Full datasets listing
PXD018743-1
PXD018743 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ubiquitination profile of polarized macrophages |
| Description | Previous studies linked mac activation with the ubiquitination (ub) status of key proteins in inflammatory signal pathways. Lysine-48 ub (K48-ub) of the NF-κB inhibitor (IκB), the final checkpoint of the NFκB pathway, leads to IκB degradation and consequent NF-κB-associated inflammation. In contrast, TRAF6, an upstream positive regulator of the NF-κB pathway, is modulated by K63-ub, leading to its conformational change and activation. However, a comprehensive analysis of ub profiles of polarized macs has not been reported. If a unique ub signature is associated with individual mac subsets is not known. |
| HostingRepository | PRIDE |
| AnnounceDate | 2020-08-06 |
| AnnouncementXML | Submission_2020-08-05_22:44:50.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xi Lin |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-04-22 15:23:28 | ID requested | |
| ⏵ 1 | 2020-08-05 22:44:50 | announced | |
| 2 | 2024-10-22 05:10:19 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: Ubiquitination, Macrophage polarization, Inflammation, LC-MS/MS |
Contact List
| Lianping Xing | |
|---|---|
| contact affiliation | University of Rochester |
| contact email | Lianping_Xing@urmc.rochester.edu |
| lab head | |
| Xi Lin | |
| contact affiliation | University of Rochester |
| contact email | Xi_Lin@urmc.rochester.edu |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/08/PXD018743 |
| PRIDE project URI |
Repository Record List
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