PXD018307-2

PXD018307 is an original dataset announced via ProteomeXchange.

Title	The Analysis of Plasma Metabolome and Lipidome of Patients with COVID-19
Description	The ongoing outbreak of novel coronavirus (SARS-CoV-2) disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization. This disease is marked by its rapid progression from mild to severe conditions, particularly in the absence of adequate medical care. And the mortality rate of COVID-19 in critically ill cases can reach over 60%. However, the physiological changes associated with COVID-19 progress under different conditions are barely understood. In this study, we performed untargeted metabolomics and lipidomic analyses of plasma from COVID-19 patients. We found a positive correlation between the alteration of metabolites and the course of disease deterioration in COVID-19 patients, indicating that the development of disease affects the metabolism of metabolites.
HostingRepository	iProX
AnnounceDate	2020-03-31
AnnouncementXML	Submission_2023-03-01_18:30:47.714.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yang Qiu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	QTRAP 6500+

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-31 05:17:55	ID requested
1	2020-06-07 21:27:55	announced
⏵ 2	2023-03-01 18:30:48	announced	2023-03-02: Update publication information.

Jing Y, Luo L, Chen Y, Westerberg LS, Zhou P, Xu Z, Herrada AA, Park CS, Kubo M, Mei H, Hu Y, Lee PP, Zheng B, Sui Z, Xiao W, Gong Q, Lu Z, Liu C, SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism. Signal Transduct Target Ther, 6(1):345(2021) [pubmed]

submitter keyword: COVID-19, plasma, metabolome, lipidome

Yang Qiu
contact affiliation	Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & Wuhan Jinyintan Hospital, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS)
contact email	yangqiu@wh.iov.cn
lab head
Yang Qiu
contact affiliation	Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & Wuhan Jinyintan Hospital, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS)
contact email	yangqiu@wh.iov.cn
dataset submitter

iProX dataset URI