Update publication information. The ongoing outbreak of novel coronavirus (SARS-CoV-2) disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization. This disease is marked by its rapid progression from mild to severe conditions, particularly in the absence of adequate medical care. And the mortality rate of COVID-19 in critically ill cases can reach over 60%. However, the physiological changes associated with COVID-19 progress under different conditions are barely understood. In this study, we performed untargeted metabolomics and lipidomic analyses of plasma from COVID-19 patients. We found a positive correlation between the alteration of metabolites and the course of disease deterioration in COVID-19 patients, indicating that the development of disease affects the metabolism of metabolites.