PXD016888-1

PXD016888 is an original dataset announced via ProteomeXchange.

Title	Label-free proteomics of secretory profiles of MRC5 treated by A549-derived exosomes or transfected with shRNAs targeting FOXN3
Description	With the in-depth study of exosomes, it has been discovered that tumor-derived exosomes could transform normal fibroblasts into cancer associated fibroblasts (CAFs) and further affect metastasis and drug resistance of CAFs, even their preference for secreting extracellular proteins, which suggest that exosomes-treated fibroblasts play an important role in promoting tumor progression through the establishment and maintainence of tumor-favored extracellular matrix. The contributions of CAFs to tumor progression are mainly mediated by secreted proteins. To better understand the role of the CAFs derived secretory proteins in tumor progression, proteomics feature of profiles of proteins secreted by fibroblast treated with A549-derived exosomes, and transfected with shRNAs targeting FOXN3, were respectively generated in triplicate.
HostingRepository	iProX
AnnounceDate	2026-03-24
AnnouncementXML	Submission_2026-03-24_01:16:38.414.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhang Jian
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-20 21:57:01	ID requested
⏵ 1	2026-03-24 01:16:39	announced

Dataset with its publication pending

submitter keyword: CAF, Exosome, fibroblast, FOXN3, lung cancer

Shuangli Mi
contact affiliation	Beijing Institute of Genomics
contact email	mishl@big.ac.cn
lab head
Zhang Jian
contact affiliation	Tianjin Medical University
contact email	zj@tmu.edu.cn
dataset submitter

iProX dataset URI