With the in-depth study of exosomes, it has been discovered that tumor-derived exosomes could transform normal fibroblasts into cancer associated fibroblasts (CAFs) and further affect metastasis and drug resistance of CAFs, even their preference for secreting extracellular proteins, which suggest that exosomes-treated fibroblasts play an important role in promoting tumor progression through the establishment and maintainence of tumor-favored extracellular matrix. The contributions of CAFs to tumor progression are mainly mediated by secreted proteins. To better understand the role of the CAFs derived secretory proteins in tumor progression, proteomics feature of profiles of proteins secreted by fibroblast treated with A549-derived exosomes, and transfected with shRNAs targeting FOXN3, were respectively generated in triplicate.