PXD016680-2
PXD016680 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | An interaction network of RNA-binding proteins involved in Drosophila oogenesis |
| Description | During Drosophila oogenesis, the localization and translational regulation of maternal transcripts relies on RNA-binding proteins (RBPs). Many of these RBPs localize several mRNAs and may have additional direct interaction partners to regulate their functions. Using immunoprecipitation from whole Drosophila ovaries coupled to mass spectrometry, we examined protein-protein associations of 6 GFP-tagged RBPs expressed at physiological levels. Analysis of the interaction network and further validation in human cells allowed us to identify 26 previously unknown associations, besides recovering several well characterized interactions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_05:07:43.761.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nicolas Nalpas |
| SpeciesList | scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-12-10 07:12:44 | ID requested | |
| 1 | 2020-06-21 22:28:00 | announced | |
| ⏵ 2 | 2024-10-22 05:07:51 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.1074/mcp.ra119.001912; |
| Bansal P, Madlung J, Schaaf K, Macek B, Bono F, Oogenesis. Mol Cell Proteomics, 19(9):1485-1502(2020) [pubmed] |
Keyword List
| curator keyword: Biological |
| submitter keyword: transgenic fly lines, LC/MS, in vitro validation, immunoprecipitation, RNA-binding proteins,Drosophila melanogaster, oogenesis |
Contact List
| Fulvia Bono | |
|---|---|
| contact affiliation | Living Systems Institute University of Exeter Exeter UK |
| contact email | F.Bono@exeter.ac.uk |
| lab head | |
| Nicolas Nalpas | |
| contact affiliation | University of Rouen |
| contact email | nalpas.nicolas@gmail.com |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD016680 |
| PRIDE project URI |
Repository Record List
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