PXD016450-2

PXD016450 is an original dataset announced via ProteomeXchange.

Title	Quantitative Proteomics Reveals the Development of HBV-associated Glomerulonephritis Triggered by the Down-regulation of SLC7A7
Description	As a hepadnavirus, hepatitis B virus (HBV) can cause damage to extrahepatic organs. The kidney is one of the organs that is more susceptible to damage. Researches on HBV-associated glomerulonephritis (HBV-GN) have been going on for decades. But the underlying molecular mechanism remains obscure. Here, we applied tandem mass tag (TMT) isobaric labeled-based method to study the protein profile of the kidney of HBV transgenic mice to illustrate the pathological mechanisms of HBV-GN. We compared a series of proteome samples from 6- and 12-month old HBV transgenic mice and their nontransgenic wild-type (WT) littermates.
HostingRepository	iProX
AnnounceDate	2019-11-27
AnnouncementXML	Submission_2020-09-03_20:55:48.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tao Zuo
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-26 18:19:57	ID requested
1	2019-11-26 18:25:43	announced
⏵ 2	2020-09-03 20:55:49	announced	2020-09-04: Update publication information

Zuo T, Chen P, Jing S, Zhang T, Chang L, Xu F, Zhao C, Xu P, Quantitative Proteomics Reveals the Development of HBV-Associated Glomerulonephritis Triggered by the Downregulation of SLC7A7. J Proteome Res, 19(4):1556-1564(2020) [pubmed]

submitter keyword: HBV-associated glomerulonephritis, transgenic mice, TMT

Ping Xu
contact affiliation	Beijing Proteome Research Center
contact email	xuping@mail.ncpsb.org
lab head
Tao Zuo
contact affiliation	Beijing Proteome Research Center
contact email	zuotao1123@163.com
dataset submitter

iProX dataset URI