Update publication information As a hepadnavirus, hepatitis B virus (HBV) can cause damage to extrahepatic organs. The kidney is one of the organs that is more susceptible to damage. Researches on HBV-associated glomerulonephritis (HBV-GN) have been going on for decades. But the underlying molecular mechanism remains obscure. Here, we applied tandem mass tag (TMT) isobaric labeled-based method to study the protein profile of the kidney of HBV transgenic mice to illustrate the pathological mechanisms of HBV-GN. We compared a series of proteome samples from 6- and 12-month old HBV transgenic mice and their nontransgenic wild-type (WT) littermates.