PXD016214 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phosphoproteomic characterization of Streptococcus pneumoniae and Influenza A virus synergism |
Description | Our understanding of the synergism between S. pneumoniae and influenza virus remains incomplete. The classic dogma has been that influenza attenuates the host innate immunity and increase the susceptibility to subsequent bacterial infection. Therefore, the majority of current studies have been focusing on the interaction of S. pneumoniae and influenza in the context of host cells. By contrast, in this study, we set out to investigate the response of pneumococcus alone to virus infection. Our hypothesis was that prior to causing any damages to host cells, influenza may have induced (lethal) changes to pneumococcus cell itself. Indeed, a very recent evidence has shown that direct viral treatment to pneumococcus will increase its adhesion to macrophage cells. Here, using quantitative phosphoproteomic approach, we attempt to investigate the global alterations of S. pneumoniae phosphorylation by influenza virus challenge, and provide a landscape of synergism between the IAV and pneumococcus. |
HostingRepository | PRIDE |
AnnounceDate | 2022-12-09 |
AnnouncementXML | Submission_2022-12-08_17:56:47.004.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | YanbaoYu |
SpeciesList | scientific name: Streptococcus pneumoniae TIGR4; NCBI TaxID: 170187; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-11-11 01:09:15 | ID requested | |
⏵ 1 | 2022-12-08 17:56:47 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Influenza A virus,Phosphoproteomics, Streptococcus pneumoniae, synergism |
Contact List
YanbaoYu |
contact affiliation | J. Craig Venter Institute 9605 Medical Center Drive Rockville, MD 20850 |
contact email | yayu@jcvi.org |
lab head | |
YanbaoYu |
contact affiliation | University of Delaware |
contact email | yayu@jcvi.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016214
- Label: PRIDE project
- Name: Phosphoproteomic characterization of Streptococcus pneumoniae and Influenza A virus synergism