PXD014195 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis |
Description | Fibro adipogenic progenitors (FAPs) promote satellite cell differentiation in adult skeletal muscle regeneration. However, in pathological conditions, FAPs are responsible for fibrosis and fatty infiltrations. Here we show that the NOTCH pathway negatively modulates FAP differentiation both in vitro and in vivo. However, FAPs isolated from young dystrophin- deficient mdx mice are insensitive to this control mechanism. An unbiased mass spectrometry-based proteomic analysis of FAPs from muscles of wild type and mdx mice, suggest that the synergistic cooperation between NOTCH and inflammatory signals controls FAP differentiation. Remarkably, we demonstrated that factors released by hematopoietic cells restore the sensitivity to NOTCH adipogenic inhibition in mdx FAPs. These results offer a basis for rationalizing pathological ectopic fat infiltrations in skeletal muscle and may suggest new therapeutic strategies to mitigate the detrimental effects of fat depositions in muscles of dystrophic patients. |
HostingRepository | PRIDE |
AnnounceDate | 2019-06-24 |
AnnouncementXML | Submission_2019-07-15_06:44:42.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Francesca Sacco |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-06-10 01:40:27 | ID requested | |
1 | 2019-06-24 06:39:09 | announced | |
⏵ 2 | 2019-07-15 06:44:43 | announced | Updated publication reference for PubMed record(s): 31239312. |
Publication List
Marinkovic M, Fuoco C, Sacco F, Cerquone Perpetuini A, Giuliani G, Micarelli E, Pavlidou T, Petrilli LL, Reggio A, Riccio F, Spada F, Vumbaca S, Zuccotti A, Castagnoli L, Mann M, Gargioli C, Cesareni G, Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis. Life Sci Alliance, 2(3):(2019) [pubmed] |
Keyword List
submitter keyword: adipogenesis, fibro adipogenic progenitors, inflammation, mass cytometry, skeletal muscle regeneration, muscular dystrophy, myopathies, NOTCH, proteome |
Contact List
Gianni Cesareni |
contact affiliation | University of Rome Tor Vergata |
contact email | cesareni@uniroma2.it |
lab head | |
Francesca Sacco |
contact affiliation | University of Rome Tor Vergata |
contact email | fsacco@biochem.mpg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014195
- Label: PRIDE project
- Name: Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis