PXD012354 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | GPIF constrains Polycomb Repressive Complex 2 activity in germ cells |
Description | The project aimed at identifying the cofactors regulating Polycomb complex PRC2 enzymatic activity in gonads. We used a knock-in mouse model where the enzymatic subunit of PRC2 (either EZH2 or EZH1) is tagged (Flag-tag) to purify PRC2 from mouse adult testis. This experiment revealed the existence of a new cofactor for PRC2 that we called GPIF (AU022751). |
HostingRepository | PRIDE |
AnnounceDate | 2019-07-22 |
AnnouncementXML | Submission_2019-07-22_09:07:22.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Pascal Jansen |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion ETD; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-01-15 07:36:37 | ID requested | |
⏵ 1 | 2019-07-22 09:07:23 | announced | |
2 | 2019-08-30 00:43:31 | announced | Updated publication reference for PubMed record(s): 31451685. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological |
submitter keyword: Chromatin, histone, methylation, Polycomb. |
Contact List
Raphaƫl Margueron |
contact affiliation | Institut Curie, Paris Sciences et Lettres Research University, INSERM U934/ CNRS, UMR3215 |
contact email | raphael.margueron@curie.fr |
lab head | |
Pascal Jansen |
contact affiliation | Radboud University |
contact email | p.jansen@science.ru.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012354
- Label: PRIDE project
- Name: GPIF constrains Polycomb Repressive Complex 2 activity in germ cells