PXD011421 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrated Quantitative Phosphoproteomics and Cell-based Functional Screening Reveals Specific Pathological Cardiac Hypertrophy-related Phosphorylation Sites |
| Description | Ventricle arrhythmias and atrial fibrillation resulting from alternation of intracellular Ca2+ handling capacity leads to pathological cardiac hypertrophy. Junctate-1 TG mouse model is considered as a genetic model of clinical relevant atrial fibrillation. Phosphorylation is one of the most important signaling cascade for cardiac hypertrophy. To further investigate the phosphoproteome changes during abnormal Ca2+ release in junctate-1, we carried out label-free LC-MS/MS coupled with IMAC phosphopeptide enrichment. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_05:25:26.973.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hye-Kyeong Kwon |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | phosphorylated residue |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2018-10-19 03:43:05 | ID requested | |
| 1 | 2021-09-08 07:21:08 | announced | |
| ⏵ 2 | 2024-10-22 05:25:29 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.14348/molcells.2021.4002; |
| Kwon HK, Choi H, Park SG, Park WJ, Kim DH, Park ZY, Integrated Quantitative Phosphoproteomics and Cell-based Functional Screening Reveals Specific Pathological Cardiac Hypertrophy-related Phosphorylation Sites. Mol Cells, 44(7):500-516(2021) [pubmed] |
Keyword List
| curator keyword: Biomedical |
| submitter keyword: Cell-based screening,LC-MS/MS, Cardiac hypertrophy, Phosphoproteome |
Contact List
| Zee-Yong Park |
|---|
| contact affiliation | Functional and Medicinal Proteomics Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea. |
| contact email | zeeyong@gist.ac.kr |
| lab head | |
| Hye-Kyeong Kwon |
|---|
| contact affiliation | Gwangju Institute of Science and Technology |
| contact email | soutenue@hotmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD011421
- Label: PRIDE project
- Name: Integrated Quantitative Phosphoproteomics and Cell-based Functional Screening Reveals Specific Pathological Cardiac Hypertrophy-related Phosphorylation Sites
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