PXD011421-1

PXD011421 is an original dataset announced via ProteomeXchange.

Title	Integrated Quantitative Phosphoproteomics and Cell-based Functional Screening Reveals Specific Pathological Cardiac Hypertrophy-related Phosphorylation Sites
Description	Ventricle arrhythmias and atrial fibrillation resulting from alternation of intracellular Ca2+ handling capacity leads to pathological cardiac hypertrophy. Junctate-1 TG mouse model is considered as a genetic model of clinical relevant atrial fibrillation. Phosphorylation is one of the most important signaling cascade for cardiac hypertrophy. To further investigate the phosphoproteome changes during abnormal Ca2+ release in junctate-1, we carried out label-free LC-MS/MS coupled with IMAC phosphopeptide enrichment.
HostingRepository	PRIDE
AnnounceDate	2021-09-08
AnnouncementXML	Submission_2021-09-08_07:21:07.857.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hye-Kyeong Kwon
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-19 03:43:05	ID requested
⏵ 1	2021-09-08 07:21:08	announced
2	2024-10-22 05:25:29	announced	2024-10-22: Updated project metadata.

Kwon HK, Choi H, Park SG, Park WJ, Kim DH, Park ZY, Integrated Quantitative Phosphoproteomics and Cell-based Functional Screening Reveals Specific Pathological Cardiac Hypertrophy-related Phosphorylation Sites. Mol Cells, 44(7):500-516(2021) [pubmed]

curator keyword: Biomedical

submitter keyword: LC-MS/MS, Cell-based screening, Cardiac hypertrophy, Phosphoproteome

Zee-Yong Park
contact affiliation	Functional and Medicinal Proteomics Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.
contact email	zeeyong@gist.ac.kr
lab head
Hye-Kyeong Kwon
contact affiliation	Gwangju Institute of Science and Technology
contact email	soutenue@hotmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD011421
     1. Label: PRIDE project
     2. Name: Integrated Quantitative Phosphoproteomics and Cell-based Functional Screening Reveals Specific Pathological Cardiac Hypertrophy-related Phosphorylation Sites