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PXD009348-1

PXD009348 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePlasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery
DescriptionObesity-related diseases now affect half of the global population, and bariatric surgery is one of the few interventions with long lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specific proteins or protein patterns may serve as key mediators and markers of the metabolic response. We performed MS-based proteomics on two longitudinal studies encompassing 47 morbidly obese patients, generating quantitative information on more than 1700 proteins. A global correlation matrix incorporating about 200,000 relationships revealed functional connections between proteins and assigned them to physiological processes. The main classes of significantly altered proteins were markers of systemic inflammation and those involved in lipid metabolism, and our data highlight robust correlative and anti-correlative behavior to each other and to clinical parameters. A group of inflammation-related proteins showed distinct inverse relationships to proteins consistently associated with insulin sensitivity.
HostingRepositoryPRIDE
AnnounceDate2018-12-07
AnnouncementXMLSubmission_2018-12-07_06:18:46.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMario Oroshi
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-03-28 00:00:02ID requested
12018-12-07 06:18:46announced
22018-12-13 00:45:18announcedUpdated publication reference for PubMed record(s): 30528273.
32024-10-22 04:44:02announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biomedical
submitter keyword: Biomarker / Diabetes / Mass Spectrometry / Obesity / Plasma Proteome Profiling / Serum / Gastric Bypass Surgery / Global correlation profiles
Contact List
Matthias Mann
contact affiliationProteomics and Signal Transduction Max Planck Institute of Biochemistry
contact emailmmann@biochem.mpg.de
lab head
Mario Oroshi
contact affiliationProteomics
contact emailoroshi@biochem.mpg.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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