PXD009348 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Plasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery |
Description | Obesity-related diseases now affect half of the global population, and bariatric surgery is one of the few interventions with long lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specific proteins or protein patterns may serve as key mediators and markers of the metabolic response. We performed MS-based proteomics on two longitudinal studies encompassing 47 morbidly obese patients, generating quantitative information on more than 1700 proteins. A global correlation matrix incorporating about 200,000 relationships revealed functional connections between proteins and assigned them to physiological processes. The main classes of significantly altered proteins were markers of systemic inflammation and those involved in lipid metabolism, and our data highlight robust correlative and anti-correlative behavior to each other and to clinical parameters. A group of inflammation-related proteins showed distinct inverse relationships to proteins consistently associated with insulin sensitivity. |
HostingRepository | PRIDE |
AnnounceDate | 2018-12-07 |
AnnouncementXML | Submission_2018-12-13_00:45:17.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mario Oroshi |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-03-28 00:00:02 | ID requested | |
1 | 2018-12-07 06:18:46 | announced | |
⏵ 2 | 2018-12-13 00:45:18 | announced | Updated publication reference for PubMed record(s): 30528273. |
Publication List
Wewer Albrechtsen NJ, Geyer PE, Doll S, Treit PV, Bojsen-M, ø, ller KN, Martinussen C, J, ø, rgensen NB, Torekov SS, Meier F, Niu L, Santos A, Keilhauer EC, Holst JJ, Madsbad S, Mann M, Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. Cell Syst, 7(6):601-612.e3(2018) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Biomarker / Diabetes / Mass Spectrometry / Obesity / Plasma Proteome Profiling / Serum / Gastric Bypass Surgery / Global correlation profiles |
Contact List
Matthias Mann |
contact affiliation | Proteomics and Signal Transduction Max Planck Institute of Biochemistry |
contact email | mmann@biochem.mpg.de |
lab head | |
Mario Oroshi |
contact affiliation | Proteomics |
contact email | oroshi@biochem.mpg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009348
- Label: PRIDE project
- Name: Plasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery