PXD009348-2

PXD009348 is an original dataset announced via ProteomeXchange.

Title	Plasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery
Description	Obesity-related diseases now affect half of the global population, and bariatric surgery is one of the few interventions with long lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specific proteins or protein patterns may serve as key mediators and markers of the metabolic response. We performed MS-based proteomics on two longitudinal studies encompassing 47 morbidly obese patients, generating quantitative information on more than 1700 proteins. A global correlation matrix incorporating about 200,000 relationships revealed functional connections between proteins and assigned them to physiological processes. The main classes of significantly altered proteins were markers of systemic inflammation and those involved in lipid metabolism, and our data highlight robust correlative and anti-correlative behavior to each other and to clinical parameters. A group of inflammation-related proteins showed distinct inverse relationships to proteins consistently associated with insulin sensitivity.
HostingRepository	PRIDE
AnnounceDate	2018-12-07
AnnouncementXML	Submission_2018-12-13_00:45:17.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Oroshi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-28 00:00:02	ID requested
1	2018-12-07 06:18:46	announced
⏵ 2	2018-12-13 00:45:18	announced	Updated publication reference for PubMed record(s): 30528273.

Wewer Albrechtsen NJ, Geyer PE, Doll S, Treit PV, Bojsen-M, ø, ller KN, Martinussen C, J, ø, rgensen NB, Torekov SS, Meier F, Niu L, Santos A, Keilhauer EC, Holst JJ, Madsbad S, Mann M, Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. Cell Syst, 7(6):601-612.e3(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Biomarker / Diabetes / Mass Spectrometry / Obesity / Plasma Proteome Profiling / Serum / Gastric Bypass Surgery / Global correlation profiles

Matthias Mann
contact affiliation	Proteomics and Signal Transduction Max Planck Institute of Biochemistry
contact email	mmann@biochem.mpg.de
lab head
Mario Oroshi
contact affiliation	Proteomics
contact email	oroshi@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/12/PXD009348

PRIDE project URI

• PRIDE
  1. PXD009348
     1. Label: PRIDE project
     2. Name: Plasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery