PXD008705-2
PXD008705 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | DiPIUS_Fbxw7 |
| Description | Although elucidation of enzyme–substrate relations is fundamental to the advancement of biology, universal approaches to the identification of substrates for a given enzyme have not been established. It is especially difficult to identify substrates for ubiquitin ligases, given that most such substrates are immediately ubiquitylated and degraded as a result of their association with the enzyme. We here describe the development of a new approach, DiPIUS (differential proteomics-based identification of ubiquitylation substrates), to the discovery of substrates for ubiquitin ligases. We applied DiPIUS to Fbxw7α, and identified candidate substrates including previously known targets. DiPIUS is thus a powerful tool for unbiased and comprehensive screening for substrates of ubiquitin ligases. |
| HostingRepository | jPOST |
| AnnounceDate | 2018-03-06 |
| AnnouncementXML | Submission_2018-09-19_00:45:35.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kanae Yumimoto |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; 2-pyrrolidone-5-carboxylic acid (Gln) |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2018-01-17 17:14:06 | ID requested | |
| 1 | 2018-03-06 00:35:30 | announced | |
| ⏵ 2 | 2018-09-19 00:45:36 | announced | Updated CV, FTP location and Modification list. |
| 3 | 2021-02-04 17:00:45 | announced | 2021-02-04: Updated FTP location. |
| 4 | 2022-09-18 03:39:02 | announced | 2022-09-18: Updated FTP location. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: substrates, Fbxw7, ubiquitin ligase |
Contact List
| Keiichi I. Nakayama | |
|---|---|
| lab head | |
| Kanae Yumimoto | |
| contact affiliation | Kyushu University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://jpost.pharm.kyoto-u.ac.jp/repository/JPST000373 |
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