PXD008564 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Aberrant Glycosylation Promotes Pancreatic Inflammation |
Description | CA19-9 is a glycan elevated in human gastrointestinal pathologies, but absent from rodents. We humanized the mouse glycome and found that CA19-9 is not only a correlative biomarker of pancreatic disease, but also plays a causative role in the initiation of pancreatitis. Elevation of CA19-9 results in the activation of EGFR signaling in the normal pancreatic ductal compartment through secretion of Fibulin 3. These signaling changes can be blocked by blocking either CA19-9 or Fibulin 3. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:12:37.149.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Keith Rivera |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iTRAQ8plex-116 reporter+balance reagent acylated residue; iodoacetic acid derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-01-02 01:33:33 | ID requested | |
1 | 2019-06-06 00:39:09 | announced | |
⏵ 2 | 2024-10-22 04:12:37 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: CA19-9 |
Contact List
David Tuveson |
contact affiliation | Cold Spring Harbor Laboratory ( lab head ) |
contact email | dtuveson@cshl.edu |
lab head | |
Keith Rivera |
contact affiliation | Cold Spring Harbor Laboratory |
contact email | krivera@cshl.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008564
- Label: PRIDE project
- Name: Aberrant Glycosylation Promotes Pancreatic Inflammation