PXD008564-1

PXD008564 is an original dataset announced via ProteomeXchange.

Title	Aberrant Glycosylation Promotes Pancreatic Inflammation
Description	CA19-9 is a glycan elevated in human gastrointestinal pathologies, but absent from rodents. We humanized the mouse glycome and found that CA19-9 is not only a correlative biomarker of pancreatic disease, but also plays a causative role in the initiation of pancreatitis. Elevation of CA19-9 results in the activation of EGFR signaling in the normal pancreatic ductal compartment through secretion of Fibulin 3. These signaling changes can be blocked by blocking either CA19-9 or Fibulin 3.
HostingRepository	PRIDE
AnnounceDate	2019-06-06
AnnouncementXML	Submission_2019-06-06_00:39:08.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Keith Rivera
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue; iodoacetic acid derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-02 01:33:33	ID requested
⏵ 1	2019-06-06 00:39:09	announced
2	2024-10-22 04:12:37	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: CA19-9

David Tuveson
contact affiliation	Cold Spring Harbor Laboratory ( lab head )
contact email	dtuveson@cshl.edu
lab head
Keith Rivera
contact affiliation	Cold Spring Harbor Laboratory
contact email	krivera@cshl.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/06/PXD008564

PRIDE project URI

• PRIDE
  1. PXD008564
     1. Label: PRIDE project
     2. Name: Aberrant Glycosylation Promotes Pancreatic Inflammation