PXD005336-3

PXD005336 is an original dataset announced via ProteomeXchange.

Title	Target Landscape of Clinical Kinase Inhibitors
Description	Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related proteins.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:16:31.426.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Susan Klaeger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; Orbitrap Fusion; Q Exactive; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-14 03:06:52	ID requested
1	2017-12-01 06:53:22	announced
2	2017-12-06 05:53:29	announced	Updated publication reference for PubMed record(s): 29191878.
⏵ 3	2024-10-22 04:16:33	announced	2024-10-22: Updated project metadata.

Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, T, õ, nisson N, Kramer K, G, ö, tze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, M, é, dard G, Jeremias I, Spiekermann K, Kuster B, The target landscape of clinical kinase drugs. Science, 358(6367):(2017) [pubmed]

10.1126/science.aan4368;

curator keyword: Biomedical

submitter keyword: target, mass spectrometry, chemical proteomics,Kinase inhibitors, clinical kinase inhibitors, selectivity, LC-MS/MS

Bernhard Kuster
contact affiliation	Chair of Proteomics and Bioanalytics, Technische Universität München, Germany
contact email	kuster@tum.de
lab head
Susan Klaeger
contact affiliation	Chair of Proteomics and Bioanalytics, TUM
contact email	Susan.Klaeger@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/12/PXD005336

PRIDE project URI

• PRIDE
  1. PXD005336
     1. Label: PRIDE project
     2. Name: Target Landscape of Clinical Kinase Inhibitors