PXD005336 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Target Landscape of Clinical Kinase Inhibitors |
Description | Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related proteins. |
HostingRepository | PRIDE |
AnnounceDate | 2017-12-01 |
AnnouncementXML | Submission_2017-12-01_06:53:20.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Susan Klaeger |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF; Orbitrap Fusion; Q Exactive; LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-11-14 03:06:52 | ID requested | |
⏵ 1 | 2017-12-01 06:53:22 | announced | |
2 | 2017-12-06 05:53:29 | announced | Updated publication reference for PubMed record(s): 29191878. |
3 | 2024-10-22 04:16:33 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biomedical |
submitter keyword: Kinase inhibitors, chemical proteomics, clinical kinase inhibitors, selectivity, target, LC-MS/MS, mass spectrometry |
Contact List
Bernhard Kuster |
contact affiliation | Chair of Proteomics and Bioanalytics, Technische Universität München, Germany |
contact email | kuster@tum.de |
lab head | |
Susan Klaeger |
contact affiliation | Chair of Proteomics and Bioanalytics, TUM |
contact email | Susan.Klaeger@tum.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/12/PXD005336 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005336
- Label: PRIDE project
- Name: Target Landscape of Clinical Kinase Inhibitors