PXD003865 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | mouse stem cell SWATH-MS . |
Description | Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to SC senescence during aging. Here we demonstrate the importance of cellular NAD+ level and its impact on mitochondrial activity as a pivotal switch to modulate muscle stem cell (MuSC) senescence. Importantly, the induction of the mitochondrial unfolded protein response (UPRmt) and of prohibitin proteins, subsequent to increasing cellular NAD+ with the precursor nicotinamide riboside (NR), rejuvenates MuSCs in aged mice. NR also prevents MuSCs senescence in Mdx mice, a mouse model of muscular dystrophy. Extending these observations to other SC pools and on the organism as a whole, we demonstrate that NR delays neural stem cell (NSC) and melanocyte stem cell (McSC) senescence, while also increasing mouse lifespan. Strategies that conserve cellular NAD+ could therefore be utilized to reprogram dysfunctional SCs in aging and disease to improve lifespan in mammals |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-07 |
AnnouncementXML | Submission_2024-10-07_10:04:10.914.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yibo Wu |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-03-29 04:31:22 | ID requested | |
⏵ 1 | 2024-10-07 10:04:16 | announced | |
2 | 2024-10-22 05:33:11 | announced | 2024-10-22: Updated project metadata. |
Publication List
Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J, repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292):1436-43(2016) [pubmed] |
10.1126/science.aaf2693; |
Keyword List
curator keyword: Biological |
submitter keyword: mouse stem cell, SWATH-MS |
Contact List
Ruedi Aebersold |
contact affiliation | IMSB, ETH Zurich, Switzerland |
contact email | aebersold@imsb.biol.ethz.ch |
lab head | |
Yibo Wu |
contact affiliation | Biology |
contact email | wu@imsb.biol.ethz.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD003865 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003865
- Label: PRIDE project
- Name: mouse stem cell SWATH-MS