PXD002214 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users |
| Description | We analyzed non-atherosclerotic repair arteries gathered at coronary by-pass operations from 30 patients with type 2 diabetes, as well as from 30 age- and gender-matched non-diabetic individuals. Quantitative proteome analysis was done by iTRAQ-labelling and LC-MS/MS analysis on individual arterial samples. The amounts of the basement membrane (BM) components, alpha-1- and alpha-2- type IV collagen, gamma-1- and beta-2-laminin were significantly increased in patients with diabetes. Moreover, the expressions of basement membrane components and other vascular proteins were significantly lower among metformin users, as compared to non-users. Patients treated with or without metformin had similar levels of HbA1c, cholesterol and blood pressure. In addition, quantitative histomorphometry showed increased area fractions of collagen-stainable material in tunica intima and media among patients with diabetes. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_04:24:30.107.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hans Christian Beck |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2015-05-21 01:22:23 | ID requested | |
| 1 | 2017-02-20 06:06:55 | announced | |
| ⏵ 2 | 2024-10-22 04:24:38 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.1161/CIRCGENETICS.115.001165; |
| Preil SA, Kristensen LP, Beck HC, Jensen PS, Nielsen PS, Steiniche T, Bj, ΓΈ, rling-Poulsen M, Larsen MR, Hansen ML, Rasmussen LM, Quantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries From Patients With Type 2 Diabetes Mellitus and Lower Levels Among Metformin Users. Circ Cardiovasc Genet, 8(5):727-35(2015) [pubmed] |
Keyword List
| curator keyword: Biomedical |
| submitter keyword: type 2 diabetes artery proteomics |
Contact List
| Hans Christian Beck |
|---|
| contact affiliation | Odense University Hospital, Sdr Boulevard 29, DK-5000 Odense C, Dept Clinical Biochemistry and Pharmacology |
| contact email | hans.christian.beck@rsyd.dk |
| lab head | |
| Hans Christian Beck |
|---|
| contact affiliation | Odense University Hospital, Odense, Denmark |
| contact email | hans.christian.beck@rsyd.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002214
- Label: PRIDE project
- Name: Quantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users
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