PXD043159-1
PXD043159 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Global Ubiquitomics Analysis of Five Life Cycle Stages of Eimeria tenella |
Description | Eimeria tenella, one of the pathogens of poultry coccidiosis, is an absolute intracellular parasite belong to phylum Apicomplexa. The parasite is highly host-specific and presents a monoxenous life cycle with multiple developmental stages. Each stage of E. tenella has different morphology, virulence, gene and protein expressions which may change through gene regulatory and post-translational modifications (PTMs) machineries. Dissecting the regulatory mechanism for E. tenella stage conversion is attractive and essential to understand parasite-host interaction. In the current study, the ubiquitome data of five developmental stages of E. tenella (unsporulated oocyst, onset of sporulation i.e., seven hours into sporulation of oocyst, sporulated oocyst, sporozoite and second-generation merozoite) were deciphered, and ubiquitomic comparison of the 5 stages were revealed. Substantially, ubiquitin conjugates were detected dynamically changed during several stages, and the protein degradation controlled by ubiquitination machinery could be the basis why some proteins accumulate and others do not in different life stages of E. tenella. In brief, we revealed the presence of ubiquitination in E. tenella and our results lay the foundation for a deeper understanding of ubiquitination and its significance in the life cycle of the avian parasite. |
HostingRepository | iProX |
AnnounceDate | 2023-06-21 |
AnnouncementXML | Submission_2023-06-21_00:00:45.255.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zigang Qu |
SpeciesList | scientific name: Eimeria tenella; NCBI TaxID: 5802; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-06-21 00:00:23 | ID requested | |
⏵ 1 | 2023-06-21 00:00:45 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: E. tenella, Ubiquitomic, Oocyst, Sporozoite, Second-generation merozoite |
Contact List
Zigang Qu | |
---|---|
contact affiliation | Lanzhou veterinary research institute, Chinese Academy of Agricultural Sciences |
contact email | quzigang@caas.cn |
lab head | |
Zigang Qu | |
contact affiliation | Lanzhou veterinary research institute, Chinese Academy of Agricultural Sciences |
contact email | quzigang@caas.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |