PXD043159

PXD043159 is an original dataset announced via ProteomeXchange.

Title	Global Ubiquitomics Analysis of Five Life Cycle Stages of Eimeria tenella
Description	Eimeria tenella, one of the pathogens of poultry coccidiosis, is an absolute intracellular parasite belong to phylum Apicomplexa. The parasite is highly host-specific and presents a monoxenous life cycle with multiple developmental stages. Each stage of E. tenella has different morphology, virulence, gene and protein expressions which may change through gene regulatory and post-translational modifications (PTMs) machineries. Dissecting the regulatory mechanism for E. tenella stage conversion is attractive and essential to understand parasite-host interaction. In the current study, the ubiquitome data of five developmental stages of E. tenella (unsporulated oocyst, onset of sporulation i.e., seven hours into sporulation of oocyst, sporulated oocyst, sporozoite and second-generation merozoite) were deciphered, and ubiquitomic comparison of the 5 stages were revealed. Substantially, ubiquitin conjugates were detected dynamically changed during several stages, and the protein degradation controlled by ubiquitination machinery could be the basis why some proteins accumulate and others do not in different life stages of E. tenella. In brief, we revealed the presence of ubiquitination in E. tenella and our results lay the foundation for a deeper understanding of ubiquitination and its significance in the life cycle of the avian parasite.
HostingRepository	iProX
AnnounceDate	2023-06-21
AnnouncementXML	Submission_2023-06-21_00:00:45.255.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zigang Qu
SpeciesList	scientific name: Eimeria tenella; NCBI TaxID: 5802;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-21 00:00:23	ID requested
⏵ 1	2023-06-21 00:00:45	announced

Dataset with its publication pending

submitter keyword: E. tenella, Ubiquitomic, Oocyst, Sporozoite, Second-generation merozoite

Zigang Qu
contact affiliation	Lanzhou veterinary research institute, Chinese Academy of Agricultural Sciences
contact email	quzigang@caas.cn
lab head
Zigang Qu
contact affiliation	Lanzhou veterinary research institute, Chinese Academy of Agricultural Sciences
contact email	quzigang@caas.cn
dataset submitter

iProX dataset URI