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PXD025164-3

PXD025164 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTemporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19
DescriptionUsing omics tools with the SARS-CoV-2 infected Syrian hamster as model for COVID-19, along with published datasets from COVID-19 patients, Nouailles et al. present a detailed longitudinal analysis of systemic and pulmonary quantitative and qualitative immune responses in a moderate disease setting. Targeted analysis of the alveolar and microvascular niche revealed a dominant role for monocyte-derived macrophages and endothelial cells regarding early anti-viral genes as well as pro-inflammatory and T cell recruiting chemokine expression. Recruitment of cytotoxic effector T cells coincided with viral clearance. This combined response was favorable for a moderate and self-limited disease course.
HostingRepositoryPRIDE
AnnounceDate2021-06-18
AnnouncementXMLSubmission_2021-09-14_22:17:34.193.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichael Mülleder
SpeciesList scientific name: Mesocricetus auratus (Golden hamster); NCBI TaxID: 10036;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive Plus; TripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-04-05 23:35:20ID requested
12021-06-17 09:18:10announced
22021-06-18 00:21:45announced2021-06-18: Updated project metadata.
32021-09-14 22:17:34announced2021-06-18: Updated project metadata.
2021-09-15: Updated publication reference for PubMed record(s): 34381043.
Publication List
Nouailles G, Wyler E, Pennitz P, Postmus D, Vladimirova D, Kazmierski J, Pott F, Dietert K, Muelleder M, Farztdinov V, Obermayer B, Wienhold SM, Andreotti S, Hoefler T, Sawitzki B, Drosten C, Sander LE, Suttorp N, Ralser M, Beule D, Gruber AD, Goffinet C, Landthaler M, Trimpert J, Witzenrath M, Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19. Nat Commun, 12(1):4869(2021) [pubmed]
Keyword List
ProteomeXchange project tag: Sars-cov-2, Covid-19
submitter keyword: Mesocricetus auratus, Sars-Cov-2
Contact List
Michael Muelleder
contact affiliationCore Facility - High-Throughput Mass Spectrometry, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany
contact emailmichael.muelleder@charite.de
lab head
Michael Mülleder
contact affiliationCore Facility -High-Throughput Mass Spectrometry, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany
contact emailmichael.muelleder@charite.de
dataset submitter
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PRIDE project URI
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