PXD025164 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19 |
Description | Using omics tools with the SARS-CoV-2 infected Syrian hamster as model for COVID-19, along with published datasets from COVID-19 patients, Nouailles et al. present a detailed longitudinal analysis of systemic and pulmonary quantitative and qualitative immune responses in a moderate disease setting. Targeted analysis of the alveolar and microvascular niche revealed a dominant role for monocyte-derived macrophages and endothelial cells regarding early anti-viral genes as well as pro-inflammatory and T cell recruiting chemokine expression. Recruitment of cytotoxic effector T cells coincided with viral clearance. This combined response was favorable for a moderate and self-limited disease course. |
HostingRepository | PRIDE |
AnnounceDate | 2021-06-18 |
AnnouncementXML | Submission_2021-09-14_22:17:34.193.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Michael Mülleder |
SpeciesList | scientific name: Mesocricetus auratus (Golden hamster); NCBI TaxID: 10036; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive Plus; TripleTOF 6600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-04-05 23:35:20 | ID requested | |
1 | 2021-06-17 09:18:10 | announced | |
2 | 2021-06-18 00:21:45 | announced | 2021-06-18: Updated project metadata. |
⏵ 3 | 2021-09-14 22:17:34 | announced | 2021-06-18: Updated project metadata.
2021-09-15: Updated publication reference for PubMed record(s): 34381043. |
Publication List
Nouailles G, Wyler E, Pennitz P, Postmus D, Vladimirova D, Kazmierski J, Pott F, Dietert K, Muelleder M, Farztdinov V, Obermayer B, Wienhold SM, Andreotti S, Hoefler T, Sawitzki B, Drosten C, Sander LE, Suttorp N, Ralser M, Beule D, Gruber AD, Goffinet C, Landthaler M, Trimpert J, Witzenrath M, Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19. Nat Commun, 12(1):4869(2021) [pubmed] |
Keyword List
ProteomeXchange project tag: Sars-cov-2, Covid-19 |
submitter keyword: Mesocricetus auratus, Sars-Cov-2 |
Contact List
Michael Muelleder |
contact affiliation | Core Facility - High-Throughput Mass Spectrometry, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany |
contact email | michael.muelleder@charite.de |
lab head | |
Michael Mülleder |
contact affiliation | Core Facility -High-Throughput Mass Spectrometry, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany |
contact email | michael.muelleder@charite.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025164
- Label: PRIDE project
- Name: Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19