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PXD025164-1

PXD025164 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLongitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2
DescriptionUsing omics tools with the SARS-CoV-2 infected Syrian hamster as model for COVID-19, along with published datasets from COVID-19 patients, Nouailles et al. present a detailed longitudinal analysis of systemic and pulmonary quantitative and qualitative immune responses in a moderate disease setting. Targeted analysis of the alveolar and microvascular niche revealed a dominant role for monocyte-derived macrophages and endothelial cells regarding early anti-viral genes as well as pro-inflammatory and T cell recruiting chemokine expression. Recruitment of cytotoxic effector T cells coincided with viral clearance. This combined response was favorable for a moderate and self-limited disease course.
HostingRepositoryPRIDE
AnnounceDate2021-06-17
AnnouncementXMLSubmission_2021-06-17_09:18:09.913.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichael Mülleder
SpeciesList scientific name: Mesocricetus auratus (Golden hamster); NCBI TaxID: 10036;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive Plus; TripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-04-05 23:35:20ID requested
12021-06-17 09:18:10announced
22021-06-18 00:21:45announced2021-06-18: Updated project metadata.
32021-09-14 22:17:34announced2021-06-18: Updated project metadata.
2021-09-15: Updated publication reference for PubMed record(s): 34381043.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Mesocricetus auratus, Sars-Cov-2,
Contact List
Michael Muelleder
contact affiliationCore Facility - High-Throughput Mass Spectrometry, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany
contact emailmichael.muelleder@charite.de
lab head
Michael Mülleder
contact affiliationCore Facility -High-Throughput Mass Spectrometry, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany
contact emailmichael.muelleder@charite.de
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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