PXD025164

PXD025164 is an original dataset announced via ProteomeXchange.

Title	Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19
Description	Using omics tools with the SARS-CoV-2 infected Syrian hamster as model for COVID-19, along with published datasets from COVID-19 patients, Nouailles et al. present a detailed longitudinal analysis of systemic and pulmonary quantitative and qualitative immune responses in a moderate disease setting. Targeted analysis of the alveolar and microvascular niche revealed a dominant role for monocyte-derived macrophages and endothelial cells regarding early anti-viral genes as well as pro-inflammatory and T cell recruiting chemokine expression. Recruitment of cytotoxic effector T cells coincided with viral clearance. This combined response was favorable for a moderate and self-limited disease course.
HostingRepository	PRIDE
AnnounceDate	2021-06-18
AnnouncementXML	Submission_2021-09-14_22:17:34.193.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Mülleder
SpeciesList	scientific name: Mesocricetus auratus (Golden hamster); NCBI TaxID: 10036;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive Plus; TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-05 23:35:20	ID requested
1	2021-06-17 09:18:10	announced
2	2021-06-18 00:21:45	announced	2021-06-18: Updated project metadata.
⏵ 3	2021-09-14 22:17:34	announced	2021-06-18: Updated project metadata. 2021-09-15: Updated publication reference for PubMed record(s): 34381043.

Nouailles G, Wyler E, Pennitz P, Postmus D, Vladimirova D, Kazmierski J, Pott F, Dietert K, Muelleder M, Farztdinov V, Obermayer B, Wienhold SM, Andreotti S, Hoefler T, Sawitzki B, Drosten C, Sander LE, Suttorp N, Ralser M, Beule D, Gruber AD, Goffinet C, Landthaler M, Trimpert J, Witzenrath M, Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19. Nat Commun, 12(1):4869(2021) [pubmed]

ProteomeXchange project tag: Sars-cov-2, Covid-19

submitter keyword: Mesocricetus auratus, Sars-Cov-2

Michael Muelleder
contact affiliation	Core Facility - High-Throughput Mass Spectrometry, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany
contact email	michael.muelleder@charite.de
lab head
Michael Mülleder
contact affiliation	Core Facility -High-Throughput Mass Spectrometry, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany
contact email	michael.muelleder@charite.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD025164

PRIDE project URI

• PRIDE
  1. PXD025164
     1. Label: PRIDE project
     2. Name: Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19