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PXD017119-1

PXD017119 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA Bartonella effector acts as signaling hub for intrinsic STAT3 activation to trigger anti-inflammatory responses
DescriptionChronically infecting pathogens avoid clearance by the innate immune system by promoting premature transition from an initial pro-inflammatory response towards an anti-inflammatory tissue-repair response. STAT3, a central regulator of inflammation, controls this transition and thus is targeted by numerous chronic pathogens. Here we show that BepD, an effector of the chronic bacterial pathogen Bartonella henselae targeted to infected host cells, establishes an exceptional pathway for canonical STAT3 activation, thereby impairing secretion of pro-inflammatory TNF-α and stimulating secretion of anti-inflammatory IL-10. Tyrosine phosphorylation of EPIYA-related motifs in BepD facilitates STAT3 binding and activation via c-Abl-dependent phosphorylation of Y705. The tyrosine-phosphorylated scaffold of BepD thus represents a signaling hub for intrinsic STAT3 activation that is independent from canonical STAT3 activation via transmembrane receptor-associated Janus kinases. We anticipate that our findings on a molecular shortcut to STAT3 activation will inspire new treatment options for chronic infections and inflammatory diseases.
HostingRepositoryPRIDE
AnnounceDate2020-02-12
AnnouncementXMLSubmission_2020-02-12_05:37:08.xml
DigitalObjectIdentifierhttp://dx.doi.org/10.6019/PXD017119
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAlexander Schmidt
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListPhospho; Oxidation; Carbamidomethyl
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-01-15 03:34:21ID requested
12020-02-12 05:37:09announced
22020-03-24 00:45:44announced2020-03-24: Updated publication reference for PubMed record(s): 32101706.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: Bartonella, Signaling, STAT3
Contact List
Alexander Schmidt
contact affiliationBiozentrum, University of Basel, Switzerland
contact emailalex.schmidt@unibas.ch
lab head
Alexander Schmidt
contact affiliationProteomics Core Facility
contact emailalex.schmidt@unibas.ch
dataset submitter
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Dataset FTP location
PRIDE project URI
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