PXD017119 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A Bartonella effector acts as signaling hub for intrinsic STAT3 activation to trigger anti-inflammatory responses |
Description | Chronically infecting pathogens avoid clearance by the innate immune system by promoting premature transition from an initial pro-inflammatory response towards an anti-inflammatory tissue-repair response. STAT3, a central regulator of inflammation, controls this transition and thus is targeted by numerous chronic pathogens. Here we show that BepD, an effector of the chronic bacterial pathogen Bartonella henselae targeted to infected host cells, establishes an exceptional pathway for canonical STAT3 activation, thereby impairing secretion of pro-inflammatory TNF-α and stimulating secretion of anti-inflammatory IL-10. Tyrosine phosphorylation of EPIYA-related motifs in BepD facilitates STAT3 binding and activation via c-Abl-dependent phosphorylation of Y705. The tyrosine-phosphorylated scaffold of BepD thus represents a signaling hub for intrinsic STAT3 activation that is independent from canonical STAT3 activation via transmembrane receptor-associated Janus kinases. We anticipate that our findings on a molecular shortcut to STAT3 activation will inspire new treatment options for chronic infections and inflammatory diseases. |
HostingRepository | PRIDE |
AnnounceDate | 2020-02-12 |
AnnouncementXML | Submission_2020-03-24_00:45:42.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD017119 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Alexander Schmidt |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | Phospho; Oxidation; Carbamidomethyl |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-01-15 03:34:21 | ID requested | |
1 | 2020-02-12 05:37:09 | announced | |
⏵ 2 | 2020-03-24 00:45:44 | announced | 2020-03-24: Updated publication reference for PubMed record(s): 32101706. |
Publication List
Sorg I, Schmutz C, Lu YY, Fromm K, Siewert LK, B, ö, gli A, Strack K, Harms A, Dehio C, A Bartonella Effector Acts as Signaling Hub for Intrinsic STAT3 Activation to Trigger Anti-inflammatory Responses. Cell Host Microbe, 27(3):476-485.e7(2020) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Bartonella, Signaling, STAT3 |
Contact List
Alexander Schmidt |
contact affiliation | Biozentrum, University of Basel, Switzerland |
contact email | alex.schmidt@unibas.ch |
lab head | |
Alexander Schmidt |
contact affiliation | Proteomics Core Facility |
contact email | alex.schmidt@unibas.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD017119
- Label: PRIDE project
- Name: A Bartonella effector acts as signaling hub for intrinsic STAT3 activation to trigger anti-inflammatory responses