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PXD015670-2

PXD015670 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of JARID2/PRC2 interactome in human embryonic stem cells
DescriptionJARID2 is an integral subunit of the chromatin modifier PRC2 (Polycomb Repressive Complex 2). PRC2 methylates lysine 27 in histone H3 and is required for human development. Mutaitons of PRC2 subunits have been frequently found in a variety of adult and pediatric cancer, suggesting that PRC2 critically regulates normal and cancer development. The goal of this project is to identify new regulator or co-factors of PRC2 and study their molecular interactions and activities in order to better understand function and regulation of PRC2 in normal and cancer development.
HostingRepositoryPRIDE
AnnounceDate2020-08-04
AnnouncementXMLSubmission_2020-09-11_03:43:27.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterVishwajeeth Pagala
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion; LTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-10-02 01:11:48ID requested
12020-08-03 22:15:02announced
22020-09-11 03:43:28announced2020-09-11: Updated publication reference for PubMed record(s): 32792512.
Publication List
Evans MK, Matsui Y, Xu B, Willis C, Loome J, Milburn L, Fan Y, Pagala V, Peng JC, Ybx1 fine-tunes PRC2 activities to control embryonic brain development. Nat Commun, 11(1):4060(2020) [pubmed]
Keyword List
submitter keyword: human embryonic stem cells
pluripotency
JARID2
PRC2
proteomics
proteome
Contact List
Jamy Peng
contact affiliationSt. Jude Children's Research Hospital, Developmental Neurobiology
contact emailJamy.peng@stjude.org
lab head
Vishwajeeth Pagala
contact affiliationSt. Jude Children's Research Hospital
contact emailvishwajeeth.pagala@stjude.org
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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