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PXD015454 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of ubiquitination site in BCL-XL after PROTAC DT2216 treatment
DescriptionThe availability of a suitable lysine for PROTAC-mediated ubiquitination can also determine the degradative ability of a protein target and the selectivity of a PROTAC. PROTAC DT2216 selectively triggers ubiquitination and degradation of BCL-XL. In this study, we identify K87 is the key ubiquitinated lysine under DT2216 treatment through LC-MS/MS.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDongwen Lv
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-09-16 01:11:27ID requested
12019-10-08 06:44:32announced
22019-12-09 23:36:44announced2019-12-10: Updated publication reference for PubMed record(s): 31792461.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: BCL-XL, Ubiquitination site, PROTAC, DT2216, K87
Contact List
Dongwen Lv
contact affiliationDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA
contact emaillyu.dongwen@cop.ufl.edu
lab head
Dongwen Lv
contact affiliationUniversity of Florida
contact emaillyu.dongwen@cop.ufl.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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