PXD015454 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification of ubiquitination site in BCL-XL after PROTAC DT2216 treatment |
Description | The availability of a suitable lysine for PROTAC-mediated ubiquitination can also determine the degradative ability of a protein target and the selectivity of a PROTAC. PROTAC DT2216 selectively triggers ubiquitination and degradation of BCL-XL. In this study, we identify K87 is the key ubiquitinated lysine under DT2216 treatment through LC-MS/MS. |
HostingRepository | PRIDE |
AnnounceDate | 2019-10-08 |
AnnouncementXML | Submission_2019-12-09_23:36:42.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Dongwen Lv |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-09-16 01:11:27 | ID requested | |
1 | 2019-10-08 06:44:32 | announced | |
⏵ 2 | 2019-12-09 23:36:44 | announced | 2019-12-10: Updated publication reference for PubMed record(s): 31792461. |
Publication List
Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D, PROTAC degrader achieves safe and potent antitumor activity. Nat Med, 25(12):1938-1947(2019) [pubmed] |
Keyword List
submitter keyword: BCL-XL, Ubiquitination site, PROTAC, DT2216, K87 |
Contact List
Dongwen Lv |
contact affiliation | Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA |
contact email | lyu.dongwen@cop.ufl.edu |
lab head | |
Dongwen Lv |
contact affiliation | University of Florida |
contact email | lyu.dongwen@cop.ufl.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD015454 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD015454
- Label: PRIDE project
- Name: Identification of ubiquitination site in BCL-XL after PROTAC DT2216 treatment