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PXD015454

PXD015454 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of ubiquitination site in BCL-XL after PROTAC DT2216 treatment
DescriptionThe availability of a suitable lysine for PROTAC-mediated ubiquitination can also determine the degradative ability of a protein target and the selectivity of a PROTAC. PROTAC DT2216 selectively triggers ubiquitination and degradation of BCL-XL. In this study, we identify K87 is the key ubiquitinated lysine under DT2216 treatment through LC-MS/MS.
HostingRepositoryPRIDE
AnnounceDate2019-10-08
AnnouncementXMLSubmission_2019-12-09_23:36:42.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDongwen Lv
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-09-16 01:11:27ID requested
12019-10-08 06:44:32announced
22019-12-09 23:36:44announced2019-12-10: Updated publication reference for PubMed record(s): 31792461.
Publication List
Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D, PROTAC degrader achieves safe and potent antitumor activity. Nat Med, 25(12):1938-1947(2019) [pubmed]
Keyword List
submitter keyword: BCL-XL, Ubiquitination site, PROTAC, DT2216, K87
Contact List
Dongwen Lv
contact affiliationDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA
contact emaillyu.dongwen@cop.ufl.edu
lab head
Dongwen Lv
contact affiliationUniversity of Florida
contact emaillyu.dongwen@cop.ufl.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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