PXD014768-2

PXD014768 is an original dataset announced via ProteomeXchange.

Title	Protective cellular mechanism of estrogen against kidney stone formation: A proteomics approach and functional validation
Description	Kidney stone disease is influenced by multiple factors, including but not limited to age, gender, genetic background, hydration status, diet and drug. Regarding the gender, epidemiologic data across the world has shown that females at the reproductive age (15-49 years) have lower incidence/prevalence of kidney stone disease approximately 1.5-2.5 folds as compared to males at the same age. However, this gap is narrower in the postmenopausal age, whereas the postmenopausal females with higher serum estrogen levels are less likely to have kidney stones. Furthermore, female stone formers (patients with kidney stones) are associated with lower estrogen levels. Therefore, estrogen has been proposed to serve as the protective hormone against kidney stone disease. However, the precise mechanisms underlying such protective effects of estrogen remain unclear and require further investigations. This study thus investigated the effects of estradiol (which is the most prevalent and potent form of estrogen in females at the reproductive age) on cellular proteome of renal tubular cells using a proteomics approach.
HostingRepository	PRIDE
AnnounceDate	2019-10-10
AnnouncementXML	Submission_2019-10-10_08:48:15.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD014768
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Visith Thongboonkerd
SpeciesList	scientific name: Canis lupus familiaris; NCBI TaxID: 9615;
ModificationList	Oxidation; Carbamidomethyl
Instrument	6550 iFunnel Q-TOF LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-26 00:59:38	ID requested
1	2019-09-10 23:54:27	announced
⏵ 2	2019-10-10 08:48:16	announced	2019-10-10: Updated project metadata.

Peerapen P, Thongboonkerd V, Protective Cellular Mechanism of Estrogen Against Kidney Stone Formation: A Proteomics Approach and Functional Validation. Proteomics, 19(19):e1900095(2019) [pubmed]

submitter keyword: Estradiol, Female, Gender

Hormone, Kidney stone, Nephrolithiasis

Prof. Visith Thongboonkerd
contact affiliation	Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
contact email	vthongbo@yahoo.com
lab head
Visith Thongboonkerd
contact affiliation	Mahidol University
contact email	sirirajms@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD014768

PRIDE project URI

• PRIDE
  1. PXD014768
     1. Label: PRIDE project
     2. Name: Protective cellular mechanism of estrogen against kidney stone formation: A proteomics approach and functional validation