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PXD014768 is an original dataset announced via ProteomeXchange.

Dataset Summary

  • Title: Protective cellular mechanism of estrogen against kidney stone formation: A proteomics approach and functional validation
  • Description: Kidney stone disease is influenced by multiple factors, including but not limited to age, gender, genetic background, hydration status, diet and drug. Regarding the gender, epidemiologic data across the world has shown that females at the reproductive age (15-49 years) have lower incidence/prevalence of kidney stone disease approximately 1.5-2.5 folds as compared to males at the same age. However, this gap is narrower in the postmenopausal age, whereas the postmenopausal females with higher serum estrogen levels are less likely to have kidney stones. Furthermore, female stone formers (patients with kidney stones) are associated with lower estrogen levels. Therefore, estrogen has been proposed to serve as the protective hormone against kidney stone disease. However, the precise mechanisms underlying such protective effects of estrogen remain unclear and require further investigations. This study thus investigated the effects of estradiol (which is the most prevalent and potent form of estrogen in females at the reproductive age) on cellular proteome of renal tubular cells using a proteomics approach.
  • HostingRepository: PRIDE
  • AnnounceDate: 2019-09-09
  • AnnouncementXML: Submission_2019-09-10_23:54:27.xml
  • DigitalObjectIdentifier: http://dx.doi.org/10.6019/PXD014768
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original dataset
  • RepositorySupport: Supported dataset by repository
  • PrimarySubmitter: Visith Thongboonkerd
  • SpeciesList: scientific name: Canis lupus familiaris; NCBI TaxID: 9615;
  • ModificationList: Oxidation; Carbamidomethyl
  • Instrument: 6550 iFunnel Q-TOF LC/MS

Dataset History

RevisionDatetimeStatusChangeLog Entry
02019-07-26 00:59:38ID requested
12019-09-10 23:54:27announced

Publication List

  1. Dataset with its publication pending

Keyword List

  1. submitter keyword: Estradiol, Female, Gender
  2. Hormone, Kidney stone, Nephrolithiasis

Contact List

    Prof. Visith Thongboonkerd
    • contact affiliation: Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    • contact email: vthongbo@yahoo.com
    • lab head:
    Visith Thongboonkerd
    • contact affiliation: Mahidol University
    • contact email: sirirajms@gmail.com
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List

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