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PXD014768

PXD014768 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProtective cellular mechanism of estrogen against kidney stone formation: A proteomics approach and functional validation
DescriptionKidney stone disease is influenced by multiple factors, including but not limited to age, gender, genetic background, hydration status, diet and drug. Regarding the gender, epidemiologic data across the world has shown that females at the reproductive age (15-49 years) have lower incidence/prevalence of kidney stone disease approximately 1.5-2.5 folds as compared to males at the same age. However, this gap is narrower in the postmenopausal age, whereas the postmenopausal females with higher serum estrogen levels are less likely to have kidney stones. Furthermore, female stone formers (patients with kidney stones) are associated with lower estrogen levels. Therefore, estrogen has been proposed to serve as the protective hormone against kidney stone disease. However, the precise mechanisms underlying such protective effects of estrogen remain unclear and require further investigations. This study thus investigated the effects of estradiol (which is the most prevalent and potent form of estrogen in females at the reproductive age) on cellular proteome of renal tubular cells using a proteomics approach.
HostingRepositoryPRIDE
AnnounceDate2019-10-10
AnnouncementXMLSubmission_2019-10-10_08:48:15.xml
DigitalObjectIdentifierhttp://dx.doi.org/10.6019/PXD014768
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterVisith Thongboonkerd
SpeciesList scientific name: Canis lupus familiaris; NCBI TaxID: 9615;
ModificationListOxidation; Carbamidomethyl
Instrument6550 iFunnel Q-TOF LC/MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-07-26 00:59:38ID requested
12019-09-10 23:54:27announced
22019-10-10 08:48:16announced2019-10-10: Updated project metadata.
Publication List
Peerapen P, Thongboonkerd V, Protective Cellular Mechanism of Estrogen Against Kidney Stone Formation: A Proteomics Approach and Functional Validation. Proteomics, 19(19):e1900095(2019) [pubmed]
Keyword List
submitter keyword: Estradiol, Female, Gender
Hormone, Kidney stone, Nephrolithiasis
Contact List
Prof. Visith Thongboonkerd
contact affiliationMedical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
contact emailvthongbo@yahoo.com
lab head
Visith Thongboonkerd
contact affiliationMahidol University
contact emailsirirajms@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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