PXD010557-4
PXD010557 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | HipSci: the iPSC proteomic compendium |
Description | Human induced pluripotent stem cell (iPSC) technology holds great potential for therapeutic and research purposes, by providing improved models of disease and for studying mechanisms regulating differentiation. The Human Induced Pluripotent Stem Cell Initiative (HipSci) was established to generate large panel of high-quality human iPSC lines from both healthy donors and disease cohorts for the research community. Here we present a resource featuring a comprehensive proteomic analysis of >200 human iPSC lines obtained from >100 different donors. This dataset has identified in total >16,000 proteins expressed in iPSCs, with expression levels spanning 7 orders of magnitude. Our analysis of these lines has provided insight into mechanisms regulating primed pluripotency. All the proteomics data we have integrated into the Enclyclopedia of Proteome Dynamics where it can be browsed and analysed interactively. https://peptracker.com/epd/analytics |
HostingRepository | PRIDE |
AnnounceDate | 2020-08-12 |
AnnouncementXML | Submission_2020-08-12_03:49:40.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alejandro Brenes |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; acetylated residue; deamidated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2018-07-25 03:00:34 | ID requested | |
1 | 2019-07-03 14:14:49 | announced | |
2 | 2019-12-16 06:44:36 | announced | 2019-12-16: Updated project metadata. |
3 | 2020-08-12 03:46:44 | announced | 2020-08-12: Updated project metadata. |
⏵ 4 | 2020-08-12 03:49:41 | announced | 2020-08-12: Updated project metadata. 2020-08-12: Updated publication reference for PubMed record(s): 32773033. 2020-08-12: Updated publication reference for DOI(s): 10.1074/mcp.RA119.001472. |
5 | 2020-08-19 05:59:55 | announced | 2020-08-12: Updated project metadata. 2020-08-12: Updated publication reference for PubMed record(s): 32773033. 2020-08-12: Updated publication reference for DOI(s): 10.1074/mcp.RA119.001472. 2020-08-19: Updated publication reference for PubMed record(s): |
6 | 2021-05-02 23:06:00 | announced | 2020-08-12: Updated project metadata. 2020-08-12: Updated publication reference for PubMed record(s): 32773033. 2020-08-12: Updated publication reference for DOI(s): 10.1074/mcp.RA119.001472. 2020-08-19: Updated publication reference for PubMed record(s): |
Publication List
10.1074/mcp.RA119.001472; |
Mirauta BA, Seaton DD, Bensaddek D, Brenes A, Bonder MJ, Kilpinen H, Stegle O, Lamond AI, Agu CA, Alderton A, Danecek P, Denton R, Durbin R, Gaffney DJ, Goncalves A, Halai R, Harper S, Kirton CM, Kolb-Kokocinski A, Leha A, McCarthy SA, Memari Y, Patel M, Birney E, Casale FP, Clarke L, Harrison PW, Kilpinen H, Streeter I, Denovi D, Stegle O, Lamond AI, Meleckyte R, Moens N, Watt FM, Ouwehand WH, Beales P, Population-scale proteome variation in human induced pluripotent stem cells. Elife, 9():(2020) [pubmed] |
Keyword List
curator keyword: Technical, Biological |
submitter keyword: proteomics, dda, tmt, orbitrap, fusion, homo sapiens, human, stem cells, ipsc |
Contact List
Angus I. Lamond | |
---|---|
contact affiliation | Centre for Gene Regulation & Expression, School of Life Sciences, University of Dundee |
contact email | a.i.lamond@dundee.ac.uk |
lab head | |
Alejandro Brenes | |
contact affiliation | University of Dundee |
contact email | ajbrenesmurillo@dundee.ac.uk |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD010557 |
PRIDE project URI |
Repository Record List
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