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PXD010557-1

PXD010557 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHipSci: the iPSC proteomic compendium
DescriptionHuman induced pluripotent stem cell (iPSC) technology holds great potential for therapeutic and research purposes, by providing improved models of disease and for studying mechanisms regulating differentiation. The Human Induced Pluripotent Stem Cell Initiative (HipSci) was established to generate large panel of high-quality human iPSC lines from both healthy donors and disease cohorts for the research community. Here we present a resource featuring a comprehensive proteomic analysis of >200 human iPSC lines obtained from >100 different donors. This dataset has identified in total >16,000 proteins expressed in iPSCs, with expression levels spanning 7 orders of magnitude. Our analysis of these lines has provided insight into mechanisms regulating primed pluripotency. All the proteomics data we have integrated into the Enclyclopedia of Proteome Dynamics where it can be browsed and analysed interactively. https://peptracker.com/epd/analytics
HostingRepositoryPRIDE
AnnounceDate2019-07-03
AnnouncementXMLSubmission_2019-07-03_14:14:48.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAlejandro Brenes
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; acetylated residue; deamidated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-07-25 03:00:34ID requested
12019-07-03 14:14:49announced
22019-12-16 06:44:36announced2019-12-16: Updated project metadata.
32020-08-12 03:46:44announced2020-08-12: Updated project metadata.
42020-08-12 03:49:41announced2020-08-12: Updated project metadata.
2020-08-12: Updated publication reference for PubMed record(s): 32773033.
2020-08-12: Updated publication reference for DOI(s): 10.1074/mcp.RA119.001472.
52020-08-19 05:59:55announced2020-08-12: Updated project metadata.
2020-08-12: Updated publication reference for PubMed record(s): 32773033.
2020-08-12: Updated publication reference for DOI(s): 10.1074/mcp.RA119.001472.
2020-08-19: Updated publication reference for PubMed record(s):
62021-05-02 23:06:00announced2020-08-12: Updated project metadata.
2020-08-12: Updated publication reference for PubMed record(s): 32773033.
2020-08-12: Updated publication reference for DOI(s): 10.1074/mcp.RA119.001472.
2020-08-19: Updated publication reference for PubMed record(s):
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Technical, Biological
submitter keyword: proteomics, dda, tmt, orbitrap, fusion, homo sapiens, human, stem cells, ipsc
Contact List
Angus I. Lamond
contact affiliationCentre for Gene Regulation & Expression, School of Life Sciences, University of Dundee
contact emaila.i.lamond@dundee.ac.uk
lab head
Alejandro Brenes
contact affiliationUniversity of Dundee
contact emailajbrenesmurillo@dundee.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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