⮝ Full datasets listing
PXD083907-1
PXD083907 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | STING Activates Megamitochondria-Mediated Lysosome Engulfment via Regulation of HK2 and VDAC1, Inducing Macrophage Senescence and M1 Polarization to Accelerate Osteoarthritis Progression |
| Description | Osteoarthritis (OA) is characterized by chronic inflammation and macrophage dysfunction, but the metabolic-immune mechanisms driving this process remain poorly understood. Here, we identify a novel and critical role for the STING pathway in OA pathogenesis, uniquely linking innate immune sensing to mitochondrial metabolic dysfunction in macrophages. |
| HostingRepository | iProX |
| AnnounceDate | 2026-09-08 |
| AnnouncementXML | Submission_2026-09-09_17:48:09.782.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hong Li |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-09-09 17:44:02 | ID requested | |
| ⏵ 1 | 2026-09-09 17:48:10 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Osteoarthritis |
Contact List
| Jiajia Lu | |
|---|---|
| contact affiliation | Shanghai Changzheng Hospital |
| contact email | shczyy_info@163.com |
| lab head | |
| Hong Li | |
| contact affiliation | Shanghai Changzheng Hospital |
| contact email | 1545559471@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
