⮝ Full datasets listing
PXD083786-1
PXD083786 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Employed an RdRp/vRNP-targeted affinity mass spectrometry-based differential analysis method-input |
| Description | Influenza virus nucleoprotein (NP) plays critical roles in viral RNA packaging and replication, a process that relies on the dynamic equilibrium between its monomeric and polymeric states. However, the regulatory mechanisms of NP’s function and fate are largely unknown. Here, we employed an RdRp/vRNP-targeted method, discovered that the cellular protein phosphatase PPM1G is a phosphatase of NP and required for maintaining viral replication. In ppm1gflox/flox-Sftpc Cre mice, lethal influenza infection led to survival and mild disease, as well as reduced lung viral loads and inflammation. PPM1G expression is upregulated upon influenza virus infection. This heightened expression occurs in response to increased viral protein production, simultaneously leading to elevated dephosphorylation of NP, which accelerates NP polymerization to promote viral replication. Meanwhile, surplus NP can be degraded through the ATG7 autophagy lysosome pathway. Our research elucidates a mechanism that PPM1G maintains vRNP homeostasis by regulating NP status and fate. |
| HostingRepository | iProX |
| AnnounceDate | 2026-09-05 |
| AnnouncementXML | Submission_2026-09-07_01:43:11.067.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mengmeng Yu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-09-07 01:42:45 | ID requested | |
| ⏵ 1 | 2026-09-07 01:43:11 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: PPM1G, nucleoprotein (NP), phosphorylation, influenza replication |
Contact List
| Xiaojun Wang | |
|---|---|
| contact affiliation | State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences |
| contact email | wangxiaojun@caas.cn |
| lab head | |
| Mengmeng Yu | |
| contact affiliation | State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences |
| contact email | yumengmeng@caas.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
