⮝ Full datasets listing
PXD083705-1
PXD083705 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | DPP9 triggers N-degron-mediated clearance of lysosome-escaped cathepsins to safeguard cells |
| Description | This dataset contains proteomics mass spectrometry raw data from an N-terminomics analysis of HEK293 DPP9 knockout cells. The study investigates DPP9-dependent processing of lysosomal cathepsins after lysosomal membrane permeabilisation, identifying mature CTSZ as a DPP9 substrate. The data support the discovery of DPP9-mediated removal of N-terminal dipeptides from cathepsins, exposing destabilising N-degrons that promote cathepsin degradation and protect cells from toxic non-lysosomal cathepsin accumulation. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-09-09 |
| AnnouncementXML | Submission_2026-09-09_09:33:07.644.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Daniel Vogele |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | TMTpro |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-09-04 09:41:19 | ID requested | |
| ⏵ 1 | 2026-09-09 09:33:08 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: cathepsins, N-terminomics, DPP9, lysosomal membrane permeabilisation, N-degron pathway, DatasetType:Proteomics |
Contact List
| Ruth Geiss-Friedlander | |
|---|---|
| contact affiliation | Institute of Molecular Medicine and Cellular Research, University of Freiburg |
| contact email | ruth.geiss-friedlander@mol-med.uni-freiburg.de |
| lab head | |
| Daniel Vogele | |
| contact affiliation | Institute of Surgical Pathology, AG Schilling |
| contact email | daniel.vogele@uniklinik-freiburg.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000101956/ |
