PXD083675-1

PXD083675 is an original dataset announced via ProteomeXchange.

Title	TFEB blockade enhances radiation-induced immunogenic cell death by exacerbating lysosomal membrane permeabilization
Description	This dataset comprises label-free quantitative DIA proteomics of the human colorectal adenocarcinoma cell line HT-29 under four conditions: untreated control, X-ray irradiation, TFEB knockdown, and TFEB knockdown plus irradiation (n = 3 biological replicates per group). The study investigates how TFEB regulates radiation-induced lysosomal membrane permeabilization (LMP), ER proteostasis and immunogenic cell death. Raw mass spectrometry files (.raw), DIA-NN v1.8.1 search results, the search FASTA database and associated metadata are provided.
HostingRepository	iProX
AnnounceDate	2026-09-03
AnnouncementXML	Submission_2026-09-04_02:05:08.791.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tianyi Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-09-04 02:04:51	ID requested
⏵ 1	2026-09-04 02:05:09	announced

Dataset with its publication pending

submitter keyword: ionizing radiation, immunogenic cell death, TFEB, lysosomal membrane permeabilization, label-free proteomics, DIA

Wenjun Wei
contact affiliation	Institute of Modern Physics, Chinese Academy of Sciences
contact email	weiwenjun@impcas.ac.cn
lab head
Tianyi Zhang
contact affiliation	Institute of Modern Physics, Chinese Academy of Sciences
contact email	chautauqualimbo@126.com
dataset submitter

iProX dataset URI