⮝ Full datasets listing
PXD083528-1
PXD083528 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-omics Analyses Demonstrate Complement Dysregulation is Involved in Focal Segmental Glomerulosclerosis |
| Description | We performed an integrative multi-omics analysis combined with histological validation. Proteomic (LC-MS/MS) profiling was conducted on renal cortical tissues from 11 patients with FSGS and 12 healthy controls from our institution, while transcriptomic (RNA-seq) analysis was performed using publicly available datasets comprising 100 FSGS and 30 normal samples. In situ deposition of key complement components (C1q, C3c, C5a, C7, CFB, CFH, MBL) was assessed using multiplex immunofluorescence confocal microscopy. Correlations between complement deposition and clinical outcomes were analyzed. |
| HostingRepository | iProX |
| AnnounceDate | 2026-09-01 |
| AnnouncementXML | Submission_2026-09-02_00:27:51.119.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yong Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | deaminated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-09-02 00:27:33 | ID requested | |
| ⏵ 1 | 2026-09-02 00:27:51 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: focal segmental glomerulosclerosis, complement, proteomics, transcriptomic, outcome |
Contact List
| Yong Zhang | |
|---|---|
| contact affiliation | West China Hospital, Sichuan University |
| contact email | nankai1989@foxmail.com |
| lab head | |
| Yong Zhang | |
| contact affiliation | West China Hospital, Sichuan University |
| contact email | nankai1989@foxmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
