PXD083512-1

PXD083512 is an original dataset announced via ProteomeXchange.

Title	Metabolic dysregulation remodels adipose tissue-derived extracellular vesicles to promote dermal fibroblast senescence and skin aging
Description	This project investigates proteomic remodeling of adipose tissue-derived extracellular vesicles (AT-EVs) under metabolic dysregulation. AT-EVs isolated from inguinal white adipose tissue of normal diet (ND)-fed and high-fat diet (HFD)-fed mice were subjected to DIA-based LC–MS/MS proteomic profiling. The analysis identified extensive differences in EV protein cargo between HFD-EVs and ND-EVs and revealed enrichment of proteins associated with metabolic, inflammatory, extracellular matrix, and secretory processes.
HostingRepository	iProX
AnnounceDate	2026-09-02
AnnouncementXML	Submission_2026-09-01_19:58:08.139.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xi Cheng
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-09-01 19:57:12	ID requested
⏵ 1	2026-09-01 19:58:08	announced

Dataset with its publication pending

submitter keyword: extracellular vesicles, adipose tissue, proteomics, metabolic dysregulation, skin aging

Qingfeng Li
contact affiliation	Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
contact email	dr.liqingfeng@shsmu.edu.cn
lab head
Xi Cheng
contact affiliation	Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
contact email	sammichengc@163.com
dataset submitter

iProX dataset URI