⮝ Full datasets listing
PXD083308-1
PXD083308 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic profiling of AP1S1-knockdown SiHa cervical cancer cells |
| Description | This study investigates the role of AP1S1 in cervical cancer progression using SiHa cervical cancer cells as a model system. We performed quantitative proteomic profiling to identify AP1S1-regulated proteins and downstream signaling pathways. Mechanistically, AP1S1 interacts with HOXC4 to suppress TRIM23-mediated ubiquitination of COX5B, thereby enhancing oxidative phosphorylation and promoting tumor cell proliferation and migration. The raw proteomics data are being deposited to support the findings of this study and to enable further re-analysis by the research community. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-27 |
| AnnouncementXML | Submission_2026-08-27_20:27:13.119.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jun Zhou |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-27 20:26:49 | ID requested | |
| ⏵ 1 | 2026-08-27 20:27:13 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: cervical cancer, AP1S1, SiHa, proteomics, oxidative phosphorylation |
Contact List
| Jun Zhou | |
|---|---|
| contact affiliation | Union Hospital, Tongji Medical College , Huazhong Science and Technology Uniersity |
| contact email | 2013xh0885@hust.edu.cn |
| lab head | |
| Jun Zhou | |
| contact affiliation | Union Hospital, Tongji Medical College , Huazhong Science and Technology Uniersity |
| contact email | 2013xh0885@hust.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
